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Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging.
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What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions - they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.
To counter this decline, we can activate the body's own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.
Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.
Special thanks to:
Professor David Sinclair, check out his book "Lifespan: Why We Age & Why We Don't Have To"
Assistant Professor David Gold
Noemie Sierra (for polyp images)
Genepool Productions for telomere animations from Immortal: https://ve42.co/immortal
Epigenetics animations (DNA, histones, methylation etc) courtesy of: http://wehi.tv
Animation: Etsuko Uno
Art and Technical Direction: Drew Berry
Sound Design: Francois Tetaz & Emma Bortignon
Scientific Consultation: Marnie Blewitt
Courtesy of Walter and Eliza Hall Institute of Medical Research
Filming, editing and animation by Jonny Hyman and Derek Muller
Music from https://epidemicsound.com "Clearer Views" "Innovations" "A Sound Foundation" "Seaweed"
Additional music by Kevin MacLeod from https://incompetech.com "Marty Gots a Plan"
Why one of the greatest inventors of all time died penniless.
*Correction: @ 7:03 It's debated who "discovered" America. The 400th anniversary of the World's Columbian Exposition of 1893 marked Christopher Columbus' voyage to the Americas.
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Sources:
0:31 Daniel Schwen / CC BY-SA 4.0 via Wikimedia Commons
1:27 Ealdgyth / CC BY-SA 3.0 via Wikimedia Commons
3:01 Jacquesverlaeken / CC BY-SA BY 3.0 via Wikimedia Commons
7:35 Tesla statue: Milan Suvajac / CC BY-SA 4.0 via Wikimedia Commons
9:00 Stanislav Kozlovskiy / CC BY-SA 3.0 via Wikimedia Commons
9:35 Original image: OneTeslaDerived image: Chetvorno / CC BY-SA 4.0 via Wikimedia Commons
9:42 Wellcome Collection CC BY 4.0 https://wellcomecollection.org/works/sq2828s9
10:17 Cardiff Council Flat Holm Project / CC BY 3.0 via Wikimedia Commons
10:54 Wellcome Collection CC BY 4.0 https://wellcomecollection.org/works/sq2828s9
Having had a good enough parent is a vital component of mental health in adulthood. But what really is a good enough parent? How can one tell if one had one or not? This film guides us as to what might have gone very right - and sometimes very wrong - in our childhoods.
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"Strangely, and rather awkwardly, it seems no human being can ever really grow up sane unless it has been loved very deeply by someone for a number of years in its early life. But we’re still learning what parental love might actually involve. The word ‘love’ trips lightly off the tongue and few parents – even the most disagreeable ones – would ever resist a claim that they felt the emotion deeply, but that doesn’t mean that loving behaviour is any easier to understand in theory or practice in reality… "
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What is the best life we can live? How can we cope with whatever the universe throws at us and keep thriving nonetheless? The ancient Greco-Roman philosophy of Stoicism explains that while we may not always have control over the events affecting us, we can have control over how we approach things. Massimo Pigliucci describes the philosophy of Stoicism.
Lesson by Massimo Pigliucci, animation by Compote Collective.
From January 2019, Scott Pelley's interview with "the oracle of AI," Kai-Fu Lee. From this past April, Pelley's report on Google's AI efforts. And from this past March, Lesley Stahl's story on chatbots like ChatGPT and a world of unknowns.
#news #artificialintelligence #technology
"60 Minutes" is the most successful television broadcast in history. Offering hard-hitting investigative reports, interviews, feature segments and profiles of people in the news, the broadcast began in 1968 and is still a hit, over 50 seasons later, regularly making Nielsen's Top 10.
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0:00 Introduction
0:11 The Oracle of AI
12:56 The Revolution (Part 1)
27:33 The Revolution (Part 2)
40:00 Who is minding the chatbots?
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If you’re new to my channel, my name is Alex Hormozi. I’m the founder and managing partner of Acquisition.com. It’s a family office, which is just a formal way of saying we invest our own money into companies. Our 10 portfolio companies bring in over $250,000,000+ per year. Our ownership stake varies between 20% and 100% of them. Given this is a YT channel, and anyone can claim anything, I’ll give you some stuff you can google to verify below.
How I got here…
21: Graduated Vanderbilt in 3 years Magna Cum Laude, and took a fancy consulting job.
23 yrs old: Left my fancy consulting job to start a business (a gym).
24 yrs old: Opened 5 gym locations.
26 yrs old: Closed down 6th gym. Lost everything.
26 yrs old: Got back to launching gyms (launched 33). Then, lost everything for a 2nd time.
26 yrs old: In desperation, started licensing model as a hail mary. It worked.
27 yrs old: "Gym Launch" does $3M profit the next 6 months. Then $17M profit next 12 months.
28 yrs old: Started Prestige Labs. $20M the first year.
29 yrs old: Launched ALAN, a software company for agencies to work leads for customers. Scaled to $1.7mmo within 6 months.
31 yrs old: Sold 75% of UseAlan to a strategic buyer in an all stock deal.
31 yrs old: Sold 66% of Gym Launch & Prestige Labs at $46.2M valuation in all-cash deal to American Pacific Group. (you can google it)
31 yrs old: Started our family office Acquisition.com. We invest and scale companies using the $42M in distributions we had taken + the cash from the $46.2M exit.
32 yrs old: Started making free content showing how we grow companies to make real business education accessible to everyone (and) to attract business owners to invest or scale their businesses.
34 yrs old: I became co-owner of https://Skool.com to help the many people who want to start a business online do so.
Today: Our portfolio now does $200M/yr between 10 companies. The largest doing $100M/yr the smallest doing $5M per year. Our ownership varies between 20% and 100% ownership of the companies. Many of them we invested in early and helped grow (which is how we make our money - not youtube videos).
To all the gladiators in the arena, we’re all in the middle of writing our own stories. The worse the monsters, the more epic the story.
You either get an epic outcome or an epic story. Both mean you win.
Keep crushing. May your desires be greater than your obstacles.
Never quit,
Alex
DISCLOSURE
Information shared here is for educational purposes only. Individuals and business owners should evaluate their own business strategies, and identify any potential risks. The information shared here is not a guarantee of success. Your results may vary.
Copyright © 2025.
Michel Foucault was a philosophical historian who questioned many of our assumptions about how much better the world is today compared with the past. When he looked at the treatment of the mad, at the medical profession and at sexuality, he didn't see the progress that's routinely assumed.
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“Michel Foucault (1926-1984) was a French 20th-century philosopher and historian who spent his career forensically critiquing the power of the modern bourgeois capitalist state, including its police, law courts, prisons, doctors and psychiatrists. His goal was to work out nothing less than how power worked and then to change it in the direction of a Marxist-anarchist utopia. Though he spent most of his life in libraries and seminar rooms, he was a committedly revolutionary figure, who met with enormous popularity in elite Parisian intellectual circles (Jean Paul Sartre admired him deeply) and still maintains a wide following among young people studying at university in the prosperous corners of the world…”
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Adding Fractions?
Subtracting Fractions?
Multiplying Fractions?
Dividing Fractions?
Mixed Numbers?
Simplifying Fractions?
It's all here.
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It really helps and is appreciated!
How Big is The Universe?
We begin at the familiar blue and green orb we call home and zoom out to explore the vastness of space. From the Moon, our closest cosmic neighbor, to the edges of the observable universe, prepare to be astonished by the sheer scale of everything that exists.
Travel with us as we venture past the Moon, understanding its distance in terms we can grasp. Witness the Sun, not just as a source of light, but as a milestone in the vastness of our solar system. We don't stop there; Mars, Neptune, and the outer reaches of our solar neighborhood await.
Discover the awe-inspiring distances to the Voyager 1 probe, the enigmatic Oort Cloud, and the neighboring star system of Alpha Centauri. As we sail through the Milky Way, understand our position in the grand scheme of things, where our entire history is just a whisper in the cosmic wind.
Our voyage takes us further, to the Local Group, Virgo Supercluster, and the staggering Laniakea Supercluster. We contemplate the Great Attractor's pull and our place in this immense heaven.
Confront the boundaries of the observable universe and ponder the mystery of what lies beyond. This video is not just a journey through space but a journey of perspective. Join us in marveling at the universe's grandeur and our humble place within it.
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#universe #sciencetime #space
A simple, elegant Pan Seared Salmon recipe in a lemon browned butter sauce. Master this easy (10-minute) method for how to cook salmon in a pan. You won’t believe the easy ingredients!
⬇️⬇️⬇️⬇️ RECIPE BELOW ⬇️⬇️⬇️⬇️
🐟 INGREDIENTS FOR PAN-SEARED SALMON:
►1 1/4 lb skinless boneless salmon filets cut into 4 filets (5 oz each about 1" thick)
►1/2 tsp salt
►1/8 tsp black pepper
►4 Tbsp unsalted butter
►1 tsp grated lemon zest
►4 Tbsp freshly squeezed lemon juice from 2 lemons
►1 Tbsp fresh parsley, minced
🖨 PRINT THIS RECIPE: https://natashaskitchen.com/pa....n-seared-salmon-with
🍽 MORE SALMON RECIPES:
►Healthy Cobb Seafood Salmon Salad with Easy Salad Dressing - https://youtu.be/Z5oocJROdsk
►Apricot Dijon Glazed Salmon and Broccoli (One Pan Meal) - https://youtu.be/vvgGk9t54XA
►Avocado Salmon Salad Recipe - https://youtu.be/vbV1h68Mnms
►Smoked Salmon Salad Recipe - Russian Shuba with a Twist - https://youtu.be/WPPARIBNRU8
►How To Make Salmon Cakes Recipe - Quick and Easy Salmon Patties -https://youtu.be/gOwBlnSmuxw
►Easy One-Pan Salmon and Asparagus Recipe - https://youtu.be/Kdq3khk_8n0
►Grilled Maple Salmon - Natasha's Kitchen - https://youtu.be/BQ2CzDsSBRM
►Baked Salmon with Garlic and Dijon - https://youtu.be/iD4bKotwdjg
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ALL OF PHYSICS in 14 Minutes: https://youtu.be/ZAqIoDhornk
Everything is made of atoms. Chemistry is the study of how they interact, and is known to be confusing, difficult, complicated...let's learn General Chemistry in under 20 Minutes.
This is not ALL of Chemistry, as fields like "Organic Chemistry" deserve videos of their own. But, this is the foundation, or "General Chemistry", which contains most concepts you need to know to understand other topics and fields of Chemistry.
This is a summary and revision of around 4 years of Chemistry you learn in school, with maybe some university level concepts sprinkled in the mix.
This video is a good summary for preparing for exams and finals. Maybe. Perhaps.
Now go learn all of Chemistry. And share this with your friends who suck at Chemistry
Timestamps:
00:00 Intro
00:16 Valence Electrons
00:34 Periodic Table
01:24 Isotopes
01:34 Ions
01:47 How to read the Periodic Table
02:09 Molecules & Compounds
02:27 Molecular Formula & Isomers
02:53 Lewis-Dot-Structures
03:03 Why atoms bond
03:26 Covalent Bonds
03:37 Electronegativity
03:54 Ionic Bonds & Salts
04:25 Metallic Bonds
04:59 Polarity
05:37 Intermolecular Forces
05:51 Hydrogen Bonds
06:00 Van der Waals Forces
06:20 Solubility
06:46 Surfactants
07:00 Forces ranked by Strength
07:07 States of Matter
07:28 Temperature & Entropy
07:49 Melting Points
08:01 Plasma & Emission Spectrum
08:35 Mixtures
09:24 Types of Chemical Reactions
09:45 Stoichiometry & Balancing Equations
10:16 The Mole
10:46 Physical vs Chemical Change
11:05 Activation Energy & Catalysts
11:24 Reaction Energy & Enthalpy
11:42 Gibbs Free Energy
12:50 Chemical Equilibriums
13:15 Acid-Base Chemistry
13:41 Acidity, Basicity, pH & pOH
14:43 Neutralisation Reactions
14:56 Redox Reactions
15:18 Oxidation Numbers
16:01 Quantum Chemistry
Music by Audionautix.com
View full lesson: http://ed.ted.com/lessons/how-....to-practice-effectiv
Mastering any physical skill takes practice. Practice is the repetition of an action with the goal of improvement, and it helps us perform with more ease, speed, and confidence. But what does practice actually do to make us better at things? Annie Bosler and Don Greene explain how practice affects the inner workings of our brains.
Lesson by Annie Bosler and Don Greene, animation by Martina Meštrović.
Does light take all possible paths at the same time
We’re incredibly grateful to Prof. David Kaiser, Prof. Steven Strogatz, Prof. Geraint F. Lewis, Elba Alonso-Monsalve, Prof. Christopher S. Baird, Prof. Anthony Bloch, and Prof. Stephen Bartlett for their invaluable contributions to this video.
A special thanks to Mahesh Shenoy from FloatHeadPhysics for his help with this video. Check out his excellent intuitive video on the UV Catastrophe here (Sep 2024): https://www.youtube.com/watch?v=ALEDjjAVZSY
▀▀▀
0:00 What path does light travel?
2:40 Black Body Radiation
6:47 How did Planck solve the ultraviolet catastrophe?
9:42 The Quantum of Action
13:25 De Broglie’s Hypothesis
15:16 The Double Slit Experiment
20:00 How Feynman Did Quantum Mechanics
25:01 Proof That Light Takes Every Path
31:16 The Theory of Everything
▀▀▀
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▀▀▀
References:
Armin Hermann (Nov 1974). The Genesis of Quantum Theory (1899-1913). - https://ve42.co/genquanttheor
Richard P. Feynman (1985). QED The Strange Theory of Light and Matter. - https://ve42.co/qed
A fantastic book on the history of the Principle of Least Action: Rojo, A. and Bloch, A. The
Principle of Least Action: History and Physics. - https://ve42.co/Bloch2018
Coopersmith, J. (2017). The lazy universe: an introduction to the principle of least action. Oxford University Press. - https://ve42.co/LazyU
PBS Space Time. (Nov 2021) - https://www.youtube.com/watch?v=Q_CQDSlmboA
Sabine Hossenfelder. (May 2022) - https://www.youtube.com/watch?v=A0da8TEeaeE
Max Planck (1901). On the Law of Distribution of Energy in the Normal Spectrum. Annalen der Physik - https://ve42.co/lawdistenergy
Paul Ehrenfest (1911). Welche Züge der Lichtquantenhypothese spielen in der Theorie der Wärmestrahlung eine wesentliche Rolle?. Wiley Online Library - https://ve42.co/quantthermrad
Nils-Erik Bomark and Reidun Renstrøm (Aug 2023). The Ultraviolet myth. Proceedings of Science - https://ve42.co/uvmyth
Planck's law. In Wikipedia - https://ve42.co/planckslaw
PBS Space Time. (Jul 2017). - https://www.youtube.com/watch?v=vSFRN-ymfgE&t=10s
Einstein and The Photoelectric Effect. (Jan 2005) via APS News - https://ve42.co/einsteinphotoelec
Louis de Broglie (1924). On the Theory of Quanta. - https://ve42.co/theoryquanta
Larry Sorensen (2012). Path Integrals 1. University of Washington - https://ve42.co/pathintegrals
Feynman’s Method of “A Particle Exploring All Possible Paths”. (Mar 2018) via Pure Dhamma - https://ve42.co/allposspaths
A great intuitive video on the Feynman path integral approach - https://www.youtube.com/watch?v=Sp5SvdDh2u8&t=1253s
Origins of Quantum Theory. via University of Pittsburgh - https://ve42.co/origquanttheor
Images & Video:
Nobistor Altona 1880 via NDR - https://ve42.co/streetlight
Edison incandescent lights by William J. Hammer via Wikimedia Commons - https://ve42.co/edinclights
The full expanded form of the Standard Model Lagrangian by Chen Ning Yang et al. via Wikipedia - https://ve42.co/stmodellang
Muon Ray. (2011). https://www.youtube.com/watch?v=-QUj2ZRUa7c
Muon Ray. (2011). https://www.youtube.com/watch?v=1C7abO7LtV0
Bohrs Atomic Model via EEEGUIDE.COM - https://ve42.co/bohrmodel
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Written by Casper Mebius and Derek Muller
Edited by Trenton Oliver and Peter Nelson
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Illustrations by Jakub Misiek, Tommy A. Steven and Cainejan Esperanza
Filmed by Derek Muller and Casper Mebius
Produced by Casper Mebius, Derek Muller, Rob Beasley Spence, Gabe Strong, Geeta Thakur, Emilia Gyles, Zoe Heron, Emily Zhang and Tori Brittain
Thumbnail contributions by Ignat Berbeci, Ben Powell, Jakub Misiek, Ren Hurley, and Peter Sheppard
Additional video/photos supplied by Getty Images and Storyblocks
Music from Epidemic Sound
More people, from their teens to young adults, are getting cancer than ever before, leaving researchers scrambling for clues. Here's what we know, and how you can protect yourself.
---------------------------#health #cancer #insidernews Insider's mission is to inform and inspire.
How does ballet convey narrative, emotion, and character? Dive into “The Sleeping Beauty” to see how a ballet creates its essential elements.
--
A baby cursed at birth. A fierce battle of good and evil. A true love awoken with a kiss. Since premiering in 1890, “The Sleeping Beauty” has become one of the most frequently staged ballets in history. So what makes this piece so beloved? And what exactly does ballet bring to this— or any other— story? Ming Luke shares what makes ballet the perfect medium for stories old and new.
Lesson by Ming Luke, directed by Visorama.
Animator's website: http://www.visorama.tv/
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Thank you so much to our patrons for your support! Without you this video would not be possible! Mehmet Yusuf Ertekin, Arlene Weston, phkphk123321, Jennifer Kurkoski, Ryan B Harvey, Austin Randall, Abhishek Bansal, Jayant Sahewal, Dian Atamyanov, igor romanenko, Jose Arcadio Valdes Franco, Brandy Sarver, Guy Hardy, Tu-Anh Nguyen, Karl Laius, Madee Lo, JY Kang, Marc Bou Zeid, Abhishek Goel, Charles A Hershberger, Coenraad Keuning, Robert Seik, Heidi Stolt, Alexis Hevia, Todd Gross, Brady Jones, Christina Salvatore, Zhong Ming Zenny Tan, Karisa Caudill, Bruno Pinho, Derek Drescher, Mihail Radu Pantilimon, Amin Shahril, Mohamed Elsayed, Barthélémy Michalon, Chumi Ogbonna, Karlee Finch, Mohammad Said, jj5252, Kelvin Lam, Mauricio Basso, Athena Grace Franco, Tirath Singh Pandher, Melvin Williams, Tsz Hin Edmund Chan, Nicolas Silva, Raymond Lee, Kurt Almendras, Denise A Pitts and Abdallah Absi.
From birth to death, tech is stretching the boundaries of biology. In this episode of Posthuman, we explore the discoveries that could transform reproduction, healthcare and how we die.
Technology that once seemed like science fiction is rapidly becoming reality, transforming the very essence of our existence. In this four-part series, Emily Chang unravels the future of being human in an age of unprecedented innovation.
This video has been updated to correct the title of Insoo Hyun, director of the Center for Life Sciences, Museum of Science.
Watch more Posthuman with Emily Chang: https://www.youtube.com/playli....st?list=PLqq4LnWs3ol
#tech #science #Posthuman
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